Lab Philosophy

"We prioritize questions over techniques."

"We value results that challenge our own models."

"We believe small perturbations can reveal governing principles of complex biological systems."

Research Overview

Classic regenerative biology focuses on stem cell behavior in isolation.

We ask instead:

When a subset of cells changes state, how does that perturb local niches, remodel tissue networks, and amplify regenerative responses?

Our recent work demonstrates that partial reprogramming can propagate widespread repair characteristics across cell types and environments.

Featured Publications

Nature Communications (2026) 

We show that mosaic partial cellular reprogramming not only alters targeted epithelial cells but also remodels neighboring microenvironments and immune networks, leading to enhanced wound healing and tissue regeneration.

▪Hair Follicle Stem Cells and Their Niches

we investigate the interaction between hair follicle stem cells and their niches

▪Cellular Identity and In Vivo Reprogramming of Epidermal Cells

we investigate how epidermal cells can be reprogrammed and the underlying mechanisms

▪Organoid

we investigate mechanisms of development and regeneration using organoids

▪Aging

we investigate structural and functional changes of the skin with aging

▪Tissue Regeneration

we investigate regeneration mechanisms by examining the interactions between stem cells and their niches during tissue regeneration